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Located on Pennsylvania Avenue in Wilmington, Santa Fe Mexican Grill features a modern twist on Mexican cuisine. Its vibrant decor and handmade Mexican artwork create a cultural dining experience for everyone. As one of Wilmington's favorite dining spots, the Santa Fe Mexican Grill in Wilmington takes pride in its homemade guacamole and freshly squeezed margaritas. Happy hour is a popular time at the restaurant because of its endless list of margaritas, sangrias, cervezas and appetizers.